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Transcriptomic Profiling across Human Serotonin Neuron Differentiation via the FEV Reporter System

ABSTRACT: This study has successfully established a human FEV reporter system using CRISPR/Cas9 gene-editing technology. We have investigated the precise timing of FEV expression in human SNs. When compared to the previously established TPH2-reporter system, the FEV-reporter system has demonstrated the capacity to yield a greater number of highly-purified SNs, which can be utilized for in-depth exploration of the transcriptomic profiles of SNs during the differentiation process. Moreover, this expanded yield of purified SNs holds promise for facilitating high-throughput drug screening.

ORGANISM(S): Homo sapiens

PROVIDER: GSE246547 | GEO | 2024/04/06

REPOSITORIES: GEO

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| EGAS00001002802 | EGA

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