Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The role of miRNAs and lncRNAs in regulating transcription in gilthead sea bream (Sparus aurata) myoblasts in response to amino acids and insulin-like growth factor 1

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Sparus aurata

PROVIDER: GSE246665 | GEO | 2024/04/17

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Exploring the Integrated Role of miRNAs and lncRNAs in Regulating the Transcriptional Response to Amino Acids and Insulin-like Growth Factor 1 in Gilthead Sea Bream (<i>Sparus aurata</i>) Myoblasts.

Project description: Not available

| S-EPMC11011856 | biostudies-literature

The role of miRNAs and lncRNAs in regulating transcription in gilthead sea bream (Sparus aurata) myoblasts in response to amino acids and insulin-like growth factor 1 [RNA-seq]

Project description:In this study, gilthead sea bream (Sparus aurata) fast muscle myoblasts were stimulated with two pro-growth treatments, amino acids (AA) and insulin-like growth factor 1 (Igf-1), to analyze the transcriptional response of genes, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) and their regulatory network. AA had a higher impact on gene transcription (1795 genes significantly changed) compared to Igf-1 (385 genes significantly changed). Both treatments stim-ulated the transcription of genes related to muscle differentiation (GO:0042692) and sarcomere components (GO:0030017), but AA stimulated more the DNA replication and cell division (GO:0007049). Notably, four miRNAs (miR-21, miR-146, miR-22b and miR-206) dominated the landscape among 403 expressed miRNAs. Both pro-growth treatments altered the transcription of over 100 miRNAs, including muscle-specific miRNAs (myomiRs) such as miR-133a/b, miR-206, miR-499, miR-1, and miR 27a. Among 111 detected lncRNAs (> 1 FPKM), only 30 were significantly changed by AA and 11 by Igf-1. Eight lncRNAs exhibited strong negative correlations with several mRNAs, suggesting direct regulation; while 30 lncRNAs showed strong correlations and interac-tions with several miRNAs, suggesting their function as miRNA’s sponges. This work is the first step in the identification of ncRNAs network controlling muscle development and growth in gilthead sea bream, pointing out potential regulatory mechanisms in response to pro-growth signals.

2024-04-17 | GSE246573 | GEO

The role of miRNAs and lncRNAs in regulating transcription in gilthead sea bream (Sparus aurata) myoblasts in response to amino acids and insulin-like growth factor 1 [miRNA-seq]

2024-04-17 | GSE246453 | GEO

A Comparative BAC map for the gilthead sea bream (Sparus aurata L.).

Project description: Not available

| S-EPMC2964914 | biostudies-literature

Experimental Horizontal Transmission of Enterospora nucleophila (Microsporea: Enterocytozoonidae) in Gilthead Sea Bream (Sparus aurata).

Project description: Not available

| S-EPMC7912876 | biostudies-literature

Characterization data of gilthead sea bream (Sparus aurata) IGF-I receptors (IGF-IRa/Rb).

Project description: Not available

| S-EPMC4724695 | biostudies-literature

Sparus aurata strain:gilthead sea bream

Project description:Gilthead sea bream genome sequencing project

| PRJEA49009 | ENA

Brewer’s spent dry yeast modulates immunity in gilthead sea bream (Sparus aurata)

Project description:We report a comparison of tissue-specific (head kidney, intestine and liver) gene expression profiles from gilthead sea bream fed with control and Brewer's spent dry yeast (SDY) diets.The inclusion of SDY at 30% in the experimental diet (40% crude protein, 16% crude lipid) resulted in a reduction in FM (10%) and PP (31.4%) contents. 218 differentially expressed genes (DEGs) were identified among all tissues, out of which, 141 were up- and 77 down-regulated. The enrichment analysis of DEGs revealed that SDY had a modulatory effect on several processes related to host’s immunity, oxygen’s carrier capacity, sexual differentiation, metabolism, and digestion. This study supports the notion that brewery’s by-products like SDY are suitable for aquafeeds of carnivorous fish species such as the gilthead sea bream, and promotes a circular bioeconomy model that reuses, recovers and recycles resources instead of producing wastes

2022-03-09 | GSE194206 | GEO

Ocean acidification promotes otolith growth and calcite deposition in gilthead sea bream (Sparus aurata) larvae.

Project description: Not available

| S-EPMC5976741 | biostudies-literature

Genetics of resistance to photobacteriosis in gilthead sea bream (Sparus aurata) using 2b-RAD sequencing.

Project description: Not available

| S-EPMC6042378 | biostudies-literature