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Transcriptomic analysis of therapy-induced senescent and diapause-like cancer cells

ABSTRACT: RNA-sequencing of proliferating, doxorubicin-induced senescent, palbociclib (CDK4/6i)-induced senescent and INK128-induced diapause-like human melanoma SK-Mel-103 cells and human NSCLC A549

ORGANISM(S): Homo sapiens

PROVIDER: GSE246690 | GEO | 2024/02/01

REPOSITORIES: GEO

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H3K9me3 and H4K29me3 CUT&Tag of therapy-induced senescent and diapause-like cancer cells

Project description:Analysis of the H3K9me3 and H4K20me3 differential localization over the genome of cancer cells in three conditions: proliferating cells, doxorubicin-treated cells (senescent) and INK128-treated cells (diapause-like). Two cell lines were used to perform the experiment: human melanoma SK-mel-103 cells and human NSCLC A549 cells.

2024-02-01 | GSE251660 | GEO

Therapy-induced senescence in a human melanoma cancer cell line

Project description:RNA-sequencing of control and senescent (7 day palbociclib) human melanoma SK-MEL-103 cells.

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Next generation sequencing of Coccinella septempunctata L. with non-diapause, diapause, and diapause-terminated states

Project description:The most commonÂ ladybird beetle, Coccinella septempunctata L., is an excellent predator of crop pests such as aphids and white flies, and it shows a wide range of adaptability, a large appetite and a high reproductive ability. In this study, we collected female adults in three different states, i.e., non-diapause, diapause and diapause termination, for transcriptome sequencing. The experimental insects consisted of three different states as follows: Non-diapause female insects were reared at 24Â±1Â°C, with a RH of 70Â±10% and a 16:8 h light: dark (L: D) photoperiod and collected after their first oviposition. Female adults in diapause were reared at 18Â±1Â°C at an RH of 70Â±10% and a 10:14-h (L:D) photoperiod. The experimental diapause insects were collected after 30 days. Diapause-terminated adults were transferred to another climatic cabinet with the 30-day diapause insects and reared under the same conditions as the non-diapause insects. After their first oviposition, the female insects were collected and stored at -80Â°C. Three biological replicates per treatment (non-diapause, diapause, diapause-terminated) were sequenced using Illumina HiSeq 2500.

2016-06-01 | E-GEOD-75645 | biostudies-arrayexpress

Transcriptional profiling of Sarcophaga crassipalpis pupal diapause

2010-05-20 | GSE20526 | GEO

Transcriptional profiling of Sarcophaga crassipalpis pupal diapause

Project description:Gene expression microarray exprement comparing differential expression between: 1) Early Diapause (ED), 2) Late Diapause (LD), 3) Non-Diapause (ND), 4) Hexane-induced diapause break (HEX). Four phenotypes (ED,ND,LD,HEX), four replicate pools of four individuals (four individuals in each replicate) in each phenotype, four competitve hybs comparing each phenotype to every other phenotype.

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ATAC-sequencing of Artemia cyst in in diapause stage and 5 hours after embryonic diapause termination

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2024-05-01 | GSE248452 | GEO

Transcriptome profiling of Artemia cyst in in diapause stage and 5 hours after embryonic diapause termination

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A genome wide CRISPR/Cas9 screening to identifiy potential embryonic diapause and diapause-like cancer cell survival genes

Project description:Diapause-like cancer cells represent a fuel for tumor relapse and strategies that leads to their elimination could be helpful in the context of minimal residual disease and tumor relapse. Here, through a genome-wide CRISPR/Cas9 screen performed in mouse embryonic stem cells undergoing diapause, we identify different genes potentially involved in the survival of diapause-like cancer cells. Further validation experiments in cancer cell lines led to the identification of the pathway NRF2-KEAP1, the 1C metabolism and the DNA methyltransferase DNMT1 as pathways involved in the survival of diapause-like cancer cells.

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Metabolic control over mTOR dependent diapause-like state

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