Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE247038 | GEO | 2023/11/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy [placenta-ncbi-cell-line_ChIPseq_cuttag]

Project description:The human placenta plays vital roles in ensuring a successful pregnancy. Despite the growing body of knowledge about its cellular compositions and functions, however, there has been limited research on the heterogeneity of the billions of nuclei within the syncytiotrophoblast (STB), a multinucleated entity primarily responsible for placental function. Here, we conducted integrated snRNA-seq and snATAC-seq on human placentas from early and late pregnancy. Our findings demonstrate the dynamic heterogeneity and developmental trajectories of STB nuclei and their presence in human trophoblast stem cells (hTSCs)-derived STB. Furthermore, we identified transcription factor (TF) motifs that are biased towards diverse STB nuclear lineages through their associated gene regulatory networks. The role of these TFs in STB differentiation were confirmed in the hTSCs- and trophoblast organoid-derived STB. Together, our data provide valuable insights into the heterogeneity of human STB and represents a valuable resource for interpreting its associated pregnancy complications.

2023-11-09 | GSE247035 | GEO

Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy [placenta-ncbi-placenta-villi_multiomic]

2023-11-09 | GSE247036 | GEO

Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy [placenta-ncbi-cell-line_scRNA-seq_snRNA-seq]

2023-11-09 | GSE247037 | GEO

Placental secretome characterization identifies candidates for pregnancy complications.

Project description: Not available

| S-EPMC8187406 | biostudies-literature

DNA Methylation Trajectories During Pregnancy.

Project description: Not available

| S-EPMC6696836 | biostudies-literature

Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy.

Project description: Not available

| S-EPMC7017452 | biostudies-literature

Unbiased placental secretome characterization identifies candidates for pregnancy complications

Project description:Proteomics assessment of supernatants, cell contents of trophoblasts were performed to identify what proteins are secreted from this particular placental region.

2021-06-09 | PXD025006 | Pride

Decidual-Placental Immune Landscape During Syngeneic Murine Pregnancy.

Project description: Not available

| S-EPMC6156255 | biostudies-literature

Gut microbiota disturbance during antibiotic therapy: a multi-omic approach.

Project description: Not available

| S-EPMC3812899 | biostudies-literature

MONET: Multi-omic module discovery by omic selection.

Project description: Not available

| S-EPMC7518594 | biostudies-literature