Spatiotemporal single-cell RNA sequencing reveals that CD4+T subpopulation with high metabolic flux plays pivotal roles under in hyperthermia treatment warts

ABSTRACT: Cutaneous wart, regarded as a benign tumor, is a proliferative disease caused by human papillomavirus (HPV) infection. Local hyperthermia at 44°C can clear multiple HPV-infected skin lesions (warts) by targeting a single lesion, which suggested that the clearance of HPV was related to the activation of T cells immunity. To identify potential inflence on T cells for anti-HPV immunity after in response to hyperthermia treatment, single-cell RNA sequencing (scRNA-seq) was performed on CA tissue samples (A type of viral warts).

ORGANISM(S): Homo sapiens

PROVIDER: GSE247043 | GEO | 2024/11/30

REPOSITORIES: GEO