EZH2 Inhibitors Promote β-like Cell Regeneration in T1D Donor tissue

ABSTRACT: β-cells are a type of endocrine cell found in pancreatic islets that synthesize, store and release insulin. Destruction of these cells in type 1 diabetes leads to a lifelong dependence on exogenous insulin administration for survival. Here we employ RNA-seq to examine the promotion of β-like cell regeneration with EZH2 inhibition in pancreatic ductal epithelial cells and exocrine cells isolated from type 1 diabetic donor tissue.

ORGANISM(S): Homo sapiens

PROVIDER: GSE247275 | GEO | 2024/01/10

REPOSITORIES: GEO