Single-cell landscape of hematopoiesis and immunological responses in patients with severe aplastic anemia treated with immunosuppression and eltrombopag

ABSTRACT: We performed single cell RNA sequencing, and VDJ sequencing of TCR and BCR of bone marrow samples (BMMMNCs and sorted CD34+ HSPCs) from 20 patients with severe aplastic anemia (SAA), pre- and post-treatment, to understand disease pathogenesis and response to treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE247531 | GEO | 2025/05/01

REPOSITORIES: GEO