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Gene expression from beagle dog mandible

ABSTRACT: In this study, beta-TCP was implanted in dog mandibles, after which the gene expression profiles and signaling pathways were monitored using microarray and Ingenuity Pathways Analysis (IPA). Following the extraction of premolars and subsequent bone healing, beta‑TCP was implanted into the artificial osseous defect. Total RNA was isolated from bone tissues and gene expression profiles were examined using microarray analysis. We used microarrays to detail the global programme of gene expression and identified distinct classes of up- and down- regulated genes during this process.

ORGANISM(S): Canis lupus familiaris

PROVIDER: GSE24756 | GEO | 2010/10/19

SECONDARY ACCESSION(S): PRJNA132155

REPOSITORIES: GEO

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Gene expression from beagle dog mandible

Project description:In this study, beta-TCP was implanted in dog mandibles, after which the gene expression profiles and signaling pathways were monitored using microarray and Ingenuity Pathways Analysis (IPA). Following the extraction of premolars and subsequent bone healing, betaâTCP was implanted into the artificial osseous defect. Total RNA was isolated from bone tissues and gene expression profiles were examined using microarray analysis. We used microarrays to detail the global programme of gene expression and identified distinct classes of up- and down- regulated genes during this process. Waiting 3 months healing after tooth extraction from beagle dog mandibles, we drilled the holes in the dog mandibles, and implanted without and with beta-TCP. And these dog mandibles were selected for RNA extraction and hybridization on Affymetrix microarrays. After implanting beta-TCP in the dog mandibles 4, 7, 14 days, we selected sample at 3 time points: Control_4d, beta-TCP_4d, Control_7d, beta-TCP_7d, Control_14d, beta-TCP_14d.

2010-10-19 | E-GEOD-24756 | biostudies-arrayexpress

Role of skeletal muscle in mandible development.

Project description:Previous analysis of Myf5-/-:MyoD-/- mouse fetuses lacking skeletal muscle demonstrated the importance of muscle contraction and static loading in mouse skeletogenesis. Previous analysis of Myf5-/-:MyoD-/- mouse fetuses lacking skeletal muscle demonstrated the importance of muscle contraction and static loading in mouse skeletogenesis. Among abnormal skeletal features, micrognathia (mandibular hypoplasia) was detected: small, bent and posteriorly displaced mandible. As an example of Waddingtonian epigenetics, we suggest that muscle, in addition to acting via mechanochemical signal transduction pathways, networks and promoters, also exerts secretory stimuli on skeleton. Our goal is to identify candidate molecules at that muscle-mandible interface. By employing Systematic Subtractive Microarray Analysis approach, we compared gene expression between mandibles of amyogenic and wild type mouse fetuses. We identified a set of candidate genes with involvement in mandibulardevelopment: Cacna1s, Ckm, Des, Mir300, Myog and Tnnc1. We also performed mouse-to-human translational experiments and found analogies. In the light of our findings we discuss various players in mandibular morphogenesis and make an argument for the need to consider mandibular development as a consequence of reciprocal epigenetic interactions of both skeletal and non-skeletal compartments.

2018-01-30 | GSE109779 | GEO

Beagle dog 90-day oral toxicity study of a novel coccidiostat - ethanamizuril.

Project description: Not available

| S-EPMC7673092 | biostudies-literature

The beagle dog MicroRNA tissue atlas: identifying translatable biomarkers of organ toxicity.

Project description: Not available

| S-EPMC4989286 | biostudies-literature

Canis lupus familiaris breed:Beagle dog

Project description:Canis lupus familiaris breed:Beagle dog Raw sequence reads

| PRJNA630302 | ENA

Canis lupus familiaris breed:Beagle dog

Project description:Global profiling of lncRNAs-miRNAs-mRNAs reveals differential expression of coding genes and non-coding RNAs in the lung of Beagle dogs at different stages of Toxocara canis infection

| PRJNA577160 | ENA

The Beagle Dog MicroRNA Tissue Atlas: Identifying Translatable Biomarkers of Organ Toxicity

Project description:Purpose : Identification of novel microRNA biomarkers specific of organ toxicity

2016-12-30 | GSE83278 | GEO

Transcriptome analysis revealed the symbiosis niche of 3D scaffolds to accelerate bone defect healing

Project description:3D printed scaffolds have been shown to be superior in promoting tissue repair, but the cell-level specific regulatory network activated by 3D printing scaffolds with different material components to form a symbiosis niche have not been systematically revealed. Here, three typical 3D printed scaffolds, including natural polymer hydrogel (Gelatin-methacryloyl, GelMA), synthetic polymer material (Polycaprolactone, PCL) and bioceramic (β-tricalcium phosphate, β-TCP), were fabricated to explore the regulating effect of the symbiotic microenvironment during bone healing. Enrichment analysis showed that hydrogel promotes tissue regeneration and reconstruction by improving blood vessel generation by enhancing oxygen transport and red blood cell development. The PCL scaffold regulates cell proliferation and differentiation by promoting cellular senescence, cell cycle and DNA replication pathways, accelerating the process of endochondral ossification and the formation of callus. The β-TCP scaffold can specifically enhance the expression of osteoclast differentiation and extracellular space pathway genes to promote the differentiation of osteoclasts and promote the process of bone remolding. In these processes, specific biomaterial properties can be used to guide cell behavior and regulate molecular network in the symbiotic microenvironment to reduce the barriers of regeneration and repair.

2021-12-06 | GSE190179 | GEO

Project description:Targeted NGS of primary bone DLBCL and other osseous DLBCL versus non-osseous DLBCL

| PRJNA681466 | ENA

Transcriptome analysis of the mandibles from FcgRIIB-deficient mouse model of lupus

Project description:To identify the extensive complexity of transcriptome in Fc gamma receptor IIB knockout (FcgRIIB−/−) mandibles. We performed gene expression profiling of mandibular bone from wild-type (WT) and FcgRIIB−/− mice at 6 months of age. Our study reports the first transcriptomic analysis in mandibles of FcgRIIB-deficient mice using RNA-sequencing (RNA-seq). The data were validated by qPCR analysis. qPCR analysis revealed similar results compared to RNA-seq data. This finding disclosed the relevant differentially expressed genes (DEGs) and clarify the mechanism underlying the pathogenesis of osteopenia. We provide novel candidate genes and enriched pathways that contribute to mandibular bone loss in FcgRIIB−/− mice during lupus development. Sufu and Serpina12 were identified as candidate molecular targets regulating osteoclastogenesis and osteogenesis, respectively.

2021-09-29 | GSE179155 | GEO

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