Molecular mechanisms of BCAT1 in ASK120067-resistant NSCLC cells

ABSTRACT: To investigate the mechanism of BCAT1 in mediating resistance to third-generation EGFR-TKI, we employed RNA-seq analysis to compare the transcriptome signature of ASK120067-resistant NSCLC cells with or without BCAT1 knockdown. Here, gene set enrichment (GSEA) revealed a significant decrease in the expression of genes in glycolysis pathway following small interfering RNA (siRNA)-mediated BCAT1 knockdown, which indicated the role for BCAT1 in supporting TKI resistance through upregulation of glycolysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE247584 | GEO | 2024/08/15

REPOSITORIES: GEO