DNA methylation alterations across time and space in paediatric brain tumours

ABSTRACT: DNA methylation is increasingly used for tumour classification and has expanded upon the > 100 currently known brain tumour entities. A correct diagnosis is the basis for suitable treatment for patients with brain tumours, which is the leading cause of cancer-related death in children. DNA methylation profiling is required for diagnosis of certain tumours, and used clinically for paediatric brain tumours in several countries. We therefore evaluated if the methylation-based classification is robust in different locations of the same tumour, and determined how the methylation pattern changed over time to relapse.

ORGANISM(S): Homo sapiens

PROVIDER: GSE247880 | GEO | 2024/03/21

REPOSITORIES: GEO