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Target genes of thyroid hormone in cerebellum neurons

ABSTRACT: Cerebellar post-natal development is particularly sensitive to thyroid hormone and low levels of thyroid hormone (hypothyroidism) result in permanent defects in cerebellar architecture and function. All cell types of the cerebellum are affected, but the main sign of hypothyroidism in mice is the persistence of the external granular layer, composed of mitotic neuronal precursors at P21. To make the genetic link between thyroid hormone and cerebellar development, we sought to identify new thyroid hormone target genes, in particular in granule cells which represent the vast majority of cerebellar cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE24793 | GEO | 2012/03/30

SECONDARY ACCESSION(S): PRJNA132251

REPOSITORIES: GEO

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Target genes of thyroid hormone in cerebellum neurons

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