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Hepatocyte growth factor(HGF) and insulin-like growth factor-1(IGF-1) for repair of bone-cartilage defects in bone marrow mesenchymal stem cells in a rabbit model of postmenopausal

ABSTRACT: In postmenopausal osteoporosis (PMOP), the differentiation of bone marrow mesenchymal stem cells (BMSCs) is unbalanced,because of the lack estrogen, that is, osteogenic differentiation is reduced, adipogenic differentiation is increased.To investigate the mechanism of aberrant differentiation of BMSCs in PMOP, we performed transcriptome sequencing of Bone marrow mesenchymal stem cells in a postmenopausal osteoporosis model(PMOP-BMSCs)and Bone marrow mesenchymal stem cells in a healthy control model(Normal-BMSCs).In this analysis, the reference transcriptome sequencing of 6 samples was completed, and the genome alignment of each sample was obtained by aligning the reads to the reference genome, and the expression of protein-coding genes was analyzed based on the alignment results. According to the expression of protein-coding genes in different samples, differential screening was performed, and a total of 1 differential group was set up.

ORGANISM(S): Leporidae

PROVIDER: GSE248225 | GEO | 2023/11/23

REPOSITORIES: GEO

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