PIK3CA and KRAS codon-specific mutations differentially toggle pathway activity and alter sensitivity to inavolisib (GDC-0077)

ABSTRACT: To explore the single and combinatorial effect of MEK and PI3KCA inhibitors in CRC lines with PIK3CA/KRAS mutations, we used the MULTI-seq CMOs to perform a highly multiplexed single-cell RNA-seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE248412 | GEO | 2025/06/15

REPOSITORIES: GEO