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MRNA microarray analysis on young adult Drosophila exposed to benzene, toluene, and formaldehyde

ABSTRACT: In order to evaluate the identification of genes and pathways, the global gene expression profiles were assessed in response to three chemicals (benzene (B), toluene (T), formaldehyde (F)) on Drosophila melanogaster. We performed whole genome DNA microarray experiments with subsequent quantitative analysis conducted on selected genes.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE24845 | GEO | 2011/12/31

SECONDARY ACCESSION(S): PRJNA133435

REPOSITORIES: GEO

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mRNA microarray analysis on young adult Drosophila exposed to benzene, toluene, and formaldehyde

Project description:In order to evaluate the identification of genes and pathways, the global gene expression profiles were assessed in response to three chemicals (benzene (B), toluene (T), formaldehyde (F)) on Drosophila melanogaster. We performed whole genome DNA microarray experiments with subsequent quantitative analysis conducted on selected genes. We used young adults of D. melanogaster exposed to B, T, or F, and whole genome microarrays to screen for global changes in D. melanogaster transcription profiles. Young adult flies were selected for RNA extraction and hybridization on Affymetrix microarrays.

2011-12-31 | E-GEOD-24845 | biostudies-arrayexpress

mRNA microarray analysis on young adult zebrafish exposed to benzene, toluene, formaldehyde and a BTF mix

2011-12-31 | GSE24846 | GEO

mRNA microarray analysis on young adult Caenorhabditis elegans exposed to benzene, toluene, formaldehyde and a BTF mix

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mRNA microarray analysis on young adult Caenorhabditis elegans, Drosophila melanogaster, and Danio rerio exposed to benzene, toluene, and formaldehyde

Project description:This SuperSeries is composed of the following subset Series: GSE23013: mRNA microarray analysis on young adult Caenorhabditis elegans exposed to benzene, toluene, formaldehyde and a BTF mix GSE24845: mRNA microarray analysis on young adult Drosophila exposed to benzene, toluene, and formaldehyde GSE24846: mRNA microarray analysis on young adult zebrafish exposed to benzene, toluene, formaldehyde and a BTF mix Refer to individual Series

2011-12-31 | E-GEOD-24923 | biostudies-arrayexpress

mRNA microarray analysis on young adult zebrafish exposed to benzene, toluene, formaldehyde and a BTF mix

Project description:In order to evaluate the identification of genes and pathways, the global gene expression profiles were assessed in response to three chemicals (benzene (B), toluene (T), formaldehyde (F)) individually and as a BTF mix on zebrafish. We performed whole genome DNA microarray experiments with subsequent quantitative analysis conducted on selected genes. We used synchronized zebrafish populations exposed to B, T, F or a BTF mix, and whole genome microarrays to screen for global changes in zebrafish transcription profiles. Young adults of zebrafish were selected for RNA extraction and hybridization on Affymetrix microarrays.

2011-12-31 | E-GEOD-24846 | biostudies-arrayexpress

mRNA microarray analysis on young adult Caenorhabditis elegans exposed to benzene, toluene, formaldehyde and a BTF mix

Project description:In order to evaluate the identification of genes and pathways, the global gene expression profiles were assessed in response to three chemicals (benzene (B), toluene (T), formaldehyde (F)) individually and as a BTF mix on the soil nematode, Caenorhabditis elegans. We performed whole genome DNA microarray experiments with subsequent quantitative analysis conducted on selected genes. We used synchronized C. elegans populations exposed to B, T, F or a BTF mix, and whole genome microarrays to screen for global changes in C. elegans transcription profiles. Young adults of C. elegans were selected for RNA extraction and hybridization on Affymetrix microarrays.

2011-12-31 | E-GEOD-23013 | biostudies-arrayexpress

Differential gene expression profiles of human promyelocytic leukemia cell line exposed to benzene toluene, and o-xylene

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Mining gene expression data for low doses of radiation and pollutants (dioxin, toluene, formaldehyde)

Project description:Expression profiles of Drosophila melanogaster in response to ionizing radiation, formaldehyde, toluene, and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

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Physiological and Transcriptional Responses of Nitrosomonas europaea to Toluene and Benzene Inhibition

Project description:The effects of the aromatic hydrocarbons benzene and toluene on Nitrosomonas europaea, a nitrifying bacterium that plays an important role in the removal of nitrogen from wastewater treatment plants, were studied in batch reactors. Exposure to 20 M toluene and 40 M benzene resulted in a 50% reduction in nitrifying activity after 1 h. However, Affymetrix microarray experiments detected no significant changes in gene expression in toluene exposed cells. Cells exposed to benzene were found to up-regulate a gene cluster (NE 1545 - NE 1551). This gene cluster appears to be involved with fatty-acid metabolism, lipid and membrane protein biosynthesis. TEM experiments reveal that cells exposed to benzene decrease the thickness of their membrane and the membrane becomes more structured. Keywords: stress response, benzene, toluene

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Differential gene expression profiles of human promyelocytic leukemia cell line exposed to benzene toluene, and o-xylene

Project description:The gene expression profiles of HL-60 cells were determined with IC50 doses of 3 chemicals (benzene, toluene, and o-xylene) at a 3 h time point. Assays were performed in triplicate for each chemical/dose, and individual gene-expression profiles were determined for each chemical at the tested concentration doses. Three independent experiments were performed for each chemical (N = 3), simultaneously. Labeling and hybridization were performed using the instructions of the Platinum Biochip Reagent Kit (GenoCheck Co. Ltd., Korea). This was followed by the coupling of the Cy3 dye for the controls (DMSO) and Cy5 dye for the treated samples. Hybridization was performed in a hybridization oven at 62 oC for 12 h. After washing (2Ã? SSC/0.1% SDS for 2 min at 58 oC, 1Ã? SSC for 2 min at RT and 0.2Ã? SSC for 3 min at RT), the slide was dried by centrifugation at 800 rpm for 3 min at RT. Hybridization images on the slides were scanned by ScanArray Lite (PerkinElmer Life Sciences, USA). Scanned images were analyzed with GenePix 3.0 software (Axon Instruments, USA) to obtain gene expression ratios.

2010-10-27 | E-GEOD-24899 | biostudies-arrayexpress

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