Project description:To further systematically probe the contribution of different cell types for brain development in MECP2T203M organoids, we performed scRNA-seq (10X genomics) on day 30 cerebral organoids.
Project description:To uncover the underlying molecular mechanisms of the low differentiation, we performed bulk RNA analysis to compare the transcriptomes of MECP2 and MECP2T203M organoids.
Project description:To evaluate whether chromatin accessibility was affected, we performed chromatin accessibility analysis of D30 cerebral organoids using ATAC-Seq.
