Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of differentially expressed tumour-related genes regulated by UHRF1 regulated DNA methylation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE248622 | GEO | 2024/05/09

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Identification of differentially expressed tumour-related genes regulated by UHRF1 regulated DNA methylation [WGBS]

Project description:UHRF1 is an epigenetic regulator that plays critical roles in tumours. However, the DNA methylation alteration patterns driven by UHRF1 and the related differentially expressed tumour-related genes remain unclear. In this study, a UHRF1-shRNA MCF-7 cell line was constructed, and whole-genome bisulfite sequencing (WGBS) and RNA sequencing were performed. The DNA methylation alteration landscape was elucidated, and DNA methylation-altered regions (DMRs) were found to be distributed in both gene bodies and adjacent regions. The DMRs were annotated and categorized into 488 hypermethylated/1696 hypomethylated promoters and 1149 hypermethylated/5501 hypomethylated gene bodies. Through an integrated analysis with the RNA sequencing data, 217 upregulated methylated genes and 288 downregulated methylated genes were identified, and these genes were primarily enriched in nervous system development and cancer signalling pathways.

2024-05-09 | GSE248621 | GEO

Identification of differentially expressed tumour-related genes regulated by UHRF1 regulated DNA methylation [RNA-Seq]

2024-05-09 | GSE248620 | GEO

Identification of differentially-expressed genes by DNA methylation in cervical cancer.

Project description: Not available

| S-EPMC4356325 | biostudies-literature

Identification of differentially expressed genes regulated by methylation in colon cancer based on bioinformatics analysis.

Project description: Not available

| S-EPMC6639549 | biostudies-literature

New differentially expressed genes and differential DNA methylation underlying refractory epilepsy.

Project description: Not available

| S-EPMC5349997 | biostudies-literature