Murine MHC-deficient NOD mice carrying human HLA-DQ8 develop severe myocarditis and myositis in response to anti-PD-1 immune-checkpoint-inhibitor cancer therapy
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ABSTRACT: Myocarditis has emerged as an immune-related adverse event of immune-checkpoint inhibitor (ICI) cancer therapy associated with significant mortality. Our new NOD-cMHCI/II-/-.DQ8 mouse strain expresses human HLA-DQ8 in the absence of classical murine MHC class I and II. These mice are highly susceptible to myocarditis and acute heart failure following anti-PD-1 ICI-induced treatment. Additionally, anti-PD-1 administration accelerates skeletal muscle myositis development. Using RNA sequencing analyses we performed a thorough characterization of cardiac and skeletal muscle infiltrating T-cells, identifying shared and unique characteristics of both populations.
ORGANISM(S): Mus musculus
PROVIDER: GSE248625 | GEO | 2024/02/02
REPOSITORIES: GEO
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