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Faecalibacterium prausnitzii promotes intestinal epithelial IL-18 production through activation of the HIF1A pathway

ABSTRACT: In this study, we investigated the regulation of interleukin-18 (IL-18) expression, crucial for intestinal barrier integrity, in inflammatory bowel disease (IBD). Through experiments with Caco-2 cells, we demonstrated that HIF1α-mediated IL18 expression induced by F. prausnitzii was dependent on HIF1α, suggesting a potential role for butyrate-producing gut bacteria in promoting mucosal healing in IBD.

ORGANISM(S): Homo sapiens

PROVIDER: GSE248806 | GEO | 2023/11/30

REPOSITORIES: GEO

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