Single-Nuclei Transcriptomic Profiling of Brown Adipose Tissue with Age

ABSTRACT: In our investigation of age-related changes in brown adipose tissue, we have identified two distinct populations of brown adipocytes characterized by high and low expression of uncoupling protein 1 (UCP1). We observed that with aging, the proportion of UCP1-low adipocytes increases, and these cells notably express genes associated with pyroptosis, an inflammatory form of programmed cell death.

ORGANISM(S): Mus musculus

PROVIDER: GSE248814 | GEO | 2024/02/24

REPOSITORIES: GEO