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An ancient enhancer rapidly evolving in the human lineage promotes neural development and cognitive flexibility

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE249253 | GEO | 2025/07/15

REPOSITORIES: GEO

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An ancient enhancer rapidly evolving in the human lineage promotes neural development and cognitive flexibility

Project description:An unsolved mystery in biology is how human-specific traits were acquired during evolution. Here, we report that an evolutionary ancient non-coding element—human accelerated region 123 (HAR123)—has undergone rapid evolution specifically in the human lineage and confers human-specific functions. HAR123 is a neural enhancer that promotes the generation of human neuroectoderm and neural progenitor cells by upregulating the transcriptional repressor HIC1. The human and chimpanzee versions of HAR123 exhibit different properties, consistent with HAR123 being selected for new functions since the human-chimpanzee split. To address the in vivo functions of HAR123, we generated HAR123-knockout mice, which exhibit a specific defect in “re-learning.” Together, our study supports a model in which HAR123 has rapidly evolved in the human lineage to influence neural generation and, ultimately, cognitive flexibility.

2025-07-15 | GSE249252 | GEO

An ancient enhancer rapidly evolving in the human lineage promotes neural development and cognitive flexibility

2025-07-15 | GSE249251 | GEO

An ancient enhancer rapidly evolving in the human lineage promotes neural development and cognitive flexibility

2025-07-15 | GSE249250 | GEO

An ancient enhancer rapidly evolving in the human lineage promotes neural development and cognitive flexibility

2025-07-15 | GSE249249 | GEO