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M2 macrophage promoting IL-10+B cell production and contribute to alleviate asthma in mouse

ABSTRACT: B cells play a crucial regulatory role in diseases. Macrophages exist in the disease microenvironment and interact with tissue cells as well as various immune cells, but their relationship with B cells has never been reported. Using an asthma animal model and macrophage depleting agents, we found that macrophage removal significantly aggravated asthma symptoms and significantly reduced the expression of IL-10+ B cells in the asthma model. We further analyzed and found that the macrophages interacting with IL-10+ B cells in the asthma microenvironment were M2 macrophages. Moreover, through sequencing, we preliminarily found that M2 macrophages promote B cell production of IL-10 through oxidative phosphorylation pathways. Together, the results indicate that M2 macrophages act on IL-10+ B cells, thereby alleviating asthma in mouse models.

ORGANISM(S): Mus musculus

PROVIDER: GSE249363 | GEO | 2025/05/14

REPOSITORIES: GEO

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