Transcriptomics

Dataset Information

0

RNA Targets and Function of Topoisomerase 3β in Reducing Stress in Neuronal Physiology


ABSTRACT: Topoisomerase 3β (Top3β) relaxes DNA and RNA and its dysregulation is implicated in various neurodevelopmental and cognitive disorders. We developed a novel protocol to isolate RNA targets of the topoisomerase without artificial cross-linking and used it to identify the RNA targets of Top3β. Lack of the enzymatic activity of Top3β affects gene expression of (pre)mRNAs with the characteristics described for the Top3β targets and we found evidence that this might also apply to several neurological diseases and cancers with which human Top3β was associated.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE249429 | GEO | 2023/12/07

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2010-03-26 | GSE21073 | GEO
2024-08-21 | GSE213403 | GEO
| PRJNA490274 | ENA
| PRJNA490272 | ENA
2005-11-05 | E-MEXP-463 | biostudies-arrayexpress
2005-11-01 | E-MEXP-462 | biostudies-arrayexpress
2011-07-22 | GSE23677 | GEO
2011-07-21 | E-GEOD-23677 | biostudies-arrayexpress
2013-08-04 | GSE47502 | GEO
2013-04-17 | GSE37352 | GEO