Absence of Anxa1 in myeloid lineage cells exacerbates acute pancreatitis (AP)

ABSTRACT: To elucidate the role of macrophage Anxa1 in the pathogenesis of AP, we intercrossed Anxa1flox/flox (Anxa1f/f or Anxa1 WT, as control) with Lyz2-Cre mice to create myeloid-specific Anxa1-knockout (Anxa1CKO) mice. We induced AP with repeated injection of cerulein in Anxa1CKO and Anxa1f/f littermates and examined the pancreas injury and inflammation. Pancreas tissue samples were collected at 12 hours after the first cerulein injection and performed RNA-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE249714 | GEO | 2023/12/15

REPOSITORIES: GEO