Myeloid PDLIM2 repression as a common causal mechanism of lung disease pathogenesis and susceptibility to infection

ABSTRACT: Selective deletion of PDLIM2 in myeloid cells rendered mice more vulnerable to lung injury and mortality after LPS intratracheal instillation, which was associated with the exacerbated activation of pro-inflammation signaling pathways and the more diminished activation of anti-inflammation signaling pathways in the lung, and particularly, in lung macrophages and neutrophils.

ORGANISM(S): Mus musculus

PROVIDER: GSE249800 | GEO | 2024/02/29

REPOSITORIES: GEO