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Analysis of MTX-3937-treated human peripheral NK cells

ABSTRACT: Siglec-9 has been of particular interest for their potential as immune checkpoints. Here, we employed docking-based virtual screening combined with bio-layer interferometry assays to identify a potential Siglec-9 inhibitor, MTX-3937. Analysis showed that MTX-3937-treatment significantly enhanced the production of IFN-γ, TNF-α, perforin and CD107a in human NK cells. Consistently, MTX-3937 largely promoted NK cells tumor killing activities both in vitro and in vivo. In mechanism, MTX-3937 inhibited the phosphorylation level of SHP-1/2 in NK92 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE250064 | GEO | 2024/01/11

REPOSITORIES: GEO

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ADAP promotes effector cytokine release, degranulation and migration 1 of NK cells primed during in vivo Listeria monocytogenes infection in 2 mice

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2020-05-27 | PXD016305 | Pride

Gene expression profiling of melanoma cell lines (carrying NF1 loss-of-function) treated with DMSO (vehicle), MTX-216, MTX-211, trametinib, the combination of MTX-216 and trametinib, or pictilisib

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Quantitative Analysis of different NK cell types Transcriptomes

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2014-01-21 | GSE53478 | GEO

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Gene profile of human monocyte-derived macrophages treated with MTX

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mRNA expression profiles in YT and NK92 cells

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2014-01-21 | E-GEOD-53478 | biostudies-arrayexpress

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2015-01-24 | E-GEOD-56426 | biostudies-arrayexpress

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