Radiation-induced amphiregulin drives tumor metastases

ABSTRACT: In this study, we demonstrate that radiation induces the epidermal growth factor receptor (EGFR) ligand amphiregulin (AREG) in tumor cells, which stimulates distant metastasis proliferation in both patients and pre-clinical murine tumor models. Using single-cell RNAseq (sc-RNAseq), we characterized the effects of AREG-induction on immune cells in the lung metastatic microenvironment of B6 mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE250375 | GEO | 2025/02/27

REPOSITORIES: GEO