Effect of depletion of Rictor on gene expression during 3% DSS treatment of colonic epithelial cells.

ABSTRACT: mTORC2 signaling is critical for maintaining cellular metabolic hemostasis. We here report mTORC2 as a key regulator of mitochondrial oxidative phosphorylation in colonic epithelial cells. The depletion of Rictor results in serious colitis after 5 days of DSS treatment. In addition, loss of Rictor impaired OXPHOS activity and ATP production. Taken together, our data provide a molecular framework for mTORC2 signaling in colonic inflammation, in which mTORC2 positively regulate mitochondrial OXPHOS activity.

ORGANISM(S): Mus musculus

PROVIDER: GSE250391 | GEO | 2025/12/18

REPOSITORIES: GEO