NF1 deficiency drives metabolic reprogramming in ER+ breast cancer

ABSTRACT: NF1 deficiency drives metabolic reprogramming in ER+ breast cancer. This reprogramming is characterized by oxidative ATP constraints, glutamine TCA influx, and lipid pool expansion, and these metabolic changes introduce novel metabolic-to-targeted inhibitor synergies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE251692 | GEO | 2023/12/25

REPOSITORIES: GEO