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Uncovering the divergent epigenetic background of KRAS-mutant NSCLC in mouse and human cell lines

ABSTRACT: Illumina miRNA-seq method to uncover the expression profile of NSCLC in-vitro experimental models consisting of cell lines A549, H460 compared to healthy BEAS-2B cell line, and lung tissue (NSCLC and paired normal) from urethane treated 6-week-old FVB/NJ mice. We aimed to uncover the divergent epigenetic background of KRAS-mutant NSCLC in mouse and human cell lines, extensively used as biological models in relevant research. To that end, we have comprehensively mapped the functional miRNA and lncRNA landscape of human (A549 and H460) and mouse (experimentally developed LUAD) NSCLC models and correlated current results with LRF/ZBTB7A expression

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE251697 | GEO | 2023/12/25

REPOSITORIES: GEO

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