Bulk RNA-seq of in vivo expanded and franformed human IgM-producing tumor cells

ABSTRACT: We are trying to quantify differences between the transformed in vivo-expanded cells and non-transformed ex vivo plasma cells isolated from paired donors. we observed strong enrichment for several pathways in EBV+IgM+ B cells including nuclear factor kappa B (NF B) activation and Myc targets. And, Genes associated with BCR-regulated pathways were upregulated in EBV+IgM+ B cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE251741 | GEO | 2023/12/26

REPOSITORIES: GEO