Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tumor intrinsic activity of Chromobox 2 (CBX2) remodels the tumor microenvironment in high grade serous carcinoma

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE251947 | GEO | 2024/07/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma.

Project description: Not available

| S-EPMC11298703 | biostudies-literature

Tumor intrinsic activity of Chromobox 2 (CBX2) remodels the tumor microenvironment in high grade serous carcinoma

Project description:Tumor intrinsic activity of Chromobox 2 (CBX2) remodels the tumor microenvironment in high grade serous carcinoma

| PRJNA1055961 | ENA

Tumor core biopsies adequately represent immune microenvironment of high-grade serous carcinoma.

Project description: Not available

| S-EPMC6879510 | biostudies-literature

Molecular Analysis of High-Grade Serous Ovarian Carcinoma Exhibiting Low-Grade Serous Carcinoma and Serous Borderline Tumor.

Project description: Not available

| S-EPMC11430742 | biostudies-literature

Changes in the tumor microenvironment mark transition from serous borderline tumor to low grade serous carcinoma

Project description:Low grade serous ovarian cancer (LGSC) is a rare subtype of ovarian cancer, characterized by a slow growth rate, resistance to current treatment regimens, multiple recurrences and poor survival. LGSC arise from serous borderline tumor (SBT), however the mechanism of transformation is poorly understood. To better understand the biology of serous ovarian tumors, we performed whole proteome profiling of LGSC, SBT and the more common high grade serous (HGSC) ovarian tumors. Proteins associated with the tumor microenvironment were differentially expressed between LGSC and SBT or HGSC. In particular, fibroblast activation protein (FAP), a protein expressed in cancer associated fibroblasts, is abundantly expressed in LGSC. Furthermore, Tregs and M2 macrophages are more abundant in the stroma of LGSC compared to SBT. Together these data suggest that the tumor microenvironment provides a supportive environment for LGSC tumorigenesis and progression, and that targeting the tumor microenvironment of LGSC may be a viable therapeutic strategy.

2024-08-15 | PXD046360 | Pride

The impact of neoadjuvant chemotherapy on the tumor microenvironment in advanced high-grade serous carcinoma.

Project description: Not available

| S-EPMC9338965 | biostudies-literature

The prognostic significance of tumor-immune microenvironment in ascites of patients with high-grade serous carcinoma.

Project description: Not available

| S-EPMC10690755 | biostudies-literature

Single-Cell RNA-Sequencing Atlas Reveals the Tumor Microenvironment of Metastatic High-Grade Serous Ovarian Carcinoma.

Project description: Not available

| S-EPMC9354882 | biostudies-literature

The spatial structure of the tumor immune microenvironment can explain and predict patient response in high-grade serous carcinoma.

Project description: Not available