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Decoding CD4+ T cell transcriptome in giant cell arteritis: novel pathways and altered cross-talk with monocytes

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE252024 | GEO | 2025/06/30

REPOSITORIES: GEO

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Decoding CD4+ T cell transcriptome in giant cell arteritis: novel pathways and altered cross-talk with monocytes [methylation]

Project description:Objectives: Giant cell arteritis (GCA) is an autoimmune large-vessels vasculitis with complex etiology. Although the pathogenic mechanisms remain poorly understood, a central role for CD4+ T cells has been demonstrated. In this context, delineating the transcriptome signatures of GCA CD4+ T cells will yield new insights into its pathogenesis. Methods: Transcriptome analysis was conducted on CD4+ T cells from 70 patients with GCA with different disease activity (active patients before treatment and patients in remission with and without glucocorticoid treatment), along with 28 healthy controls. The study also evaluated potential impacts of DNA methylation on gene expression alterations and assessed cross-talk communication with CD14+ monocytes. Results: This study has uncovered a substantial number of genes and pathways potentially contributing to the pathogenicity of CD4+ T cells in GCA. Specifically, CD4+ T cells from GCA patients with active disease exhibited altered expression levels of genes involved in multiple immune-related processes, including various interleukins (IL) signaling pathways. Notably, IL-2, a decisive interleukin for regulatory T cells homeostasis, was among the most significant. Additionally, impaired apoptotic pathways appear to be crucial in GCA development. Our findings also suggest that histone-related epigenetic pathways may be implicated in promoting an inflammatory phenotype in GCA active patients. Finally, our study observed altered signaling communication, such as the Jagged-Notch signaling, between CD4+ T cells and monocytes that could have pathogenic relevance in GCA. Conclusions: Our study suggests the participation of novel cytokines and pathways and the occurrence of a disruption of monocyte-T cell crosstalk driving GCA pathogenesis.

2025-06-30 | GSE252021 | GEO

Decoding CD4+ T cell transcriptome in giant cell arteritis: novel pathways and altered cross-talk with monocytes [RNA-seq]

2025-06-30 | GSE252020 | GEO

Decoding CD4+ T cell transcriptome in giant cell arteritis: novel pathways and altered cross-talk with monocytes

Project description:Decoding CD4+ T cell transcriptome in giant cell arteritis: novel pathways and altered cross-talk with monocytes

| PRJNA1057134 | ENA

Decoding CD4+ T cell transcriptome in giant cell arteritis: novel pathways and altered cross-talk with monocytes [methylation]

Project description:Decoding CD4+ T cell transcriptome in giant cell arteritis: novel pathways and altered cross-talk with monocytes [methylation]

| PRJNA1057132 | ENA

Decoding CD4+ T cell transcriptome in giant cell arteritis: novel pathways and altered cross-talk with monocytes [RNA-seq]

Project description:Decoding CD4+ T cell transcriptome in giant cell arteritis: novel pathways and altered cross-talk with monocytes [RNA-seq]

| PRJNA1057133 | ENA

CD4 T cells in Giant Cell Arteritis

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-09-08 | GSE224528 | GEO

Giant cell arteritis.

Project description: Not available

| S-EPMC3060188 | biostudies-literature

CD4 T cells in Giant Cell Arteritis (scRNA-Seq)

Project description:CD4 T cells are important in GCA