The effect of myeloid STING knockout on gene expression in colitic mice

ABSTRACT: Myeloid-derived STING has been recognized to play a vital role in mediating the development of colitis. We here report that myeloid-specific knockout of STING in adult mice ameliorates DSS-induced acute colitis through inhibiting macrophage maturation, reducing DC cell activation, and suppressing pro-inflammatory Th1 and Th17 cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE252100 | GEO | 2024/08/14

REPOSITORIES: GEO