Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma (single-cell RNA-seq analysis)

ABSTRACT: A single-cell analysis (10x) of p53/MCA induced sarcomas tumors with and without radiation and CpG treatment. p53/MCA induced sarcomes are induced by intramuscular injection of adenovirus expressing Cas9 and sgRNA targeting Trp53 (Adeno-p53-sgRNA; Viraquest) at gastrucnemius muscle site. We used scRNA-seq to analyze the differences in immune cells after treatment with CpG+RT

ORGANISM(S): Mus musculus

PROVIDER: GSE252143 | GEO | 2024/01/01

REPOSITORIES: GEO