Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma

ABSTRACT: p53/MCA sarcomas are induced by intramuscular injection of adenovirus expressing Cas9 and sgRNA targeting Trp53 (Adeno-p53-sgRNA; Viraquest) at gastrucnemius muscle site. We used bulk tumor RNAseq to analyze the differences in tumor cells and immune cells after treatment with CpG+RT

ORGANISM(S): Mus musculus

PROVIDER: GSE252213 | GEO | 2024/01/01

REPOSITORIES: GEO