Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CBX4 in Lung Adenocarcinoma: A Dual-Edged Sword in Transcriptional Regulation and Tumor Progression

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE252231 | GEO | 2024/01/05

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

CBX4 in Lung Adenocarcinoma: A Dual-Edged Sword in Transcriptional Regulation and Tumor Progression [RNA-seq]

Project description:Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality worldwide. Understanding the dysregulated epigenetics governing LUAD progression is pivotal for identifying therapeutic targets. CBX4, a chromobox protein, is reported to be upregulated in LUAD. However, its regulatory role in LUAD progression warrants in-depth investigation. This study highlights the dual impact of CBX4 on LUAD proliferation and metastasis. Through a series of rigorous in vitro and in vivo experiments, we elucidate that CBX4 functions in promoting LUAD proliferation via upregulating PHGDH expression while concurrently suppressing LUAD metastasis by inhibiting ZEB2 transcription. Further investigation into the underlying mechanism reveals CBX4’s intricate interactions with distinct epigenetic factors. The inhibition of ZEB2 transcription involves CBX4-mediated recruitment of canonical PRC1 (cPRC1), establishing H2K119ub on the ZEB2 promoter. Simultaneously, CBX4 facilitates PHGDH transcription through interaction with GCN5, inducing heightened histone acetylation on the PHGDH promoter. These findings underscore CBX4's pivotal role as a regulator of LUAD progression, emphasizing its diverse transcriptional regulatory functions contingent upon interactions with specific epigenetic partners. Understanding the nuanced interplay between CBX4 and epigenetic factors sheds light on potential therapeutic avenues in LUAD.

2024-01-05 | GSE252181 | GEO

CBX4 in Lung Adenocarcinoma: A Dual-Edged Sword in Transcriptional Regulation and Tumor Progression [ChIP-Seq]

2024-01-05 | GSE252230 | GEO

Lung adenocarcinoma invasion and progression

Project description:This SuperSeries is composed of the SubSeries listed below.

2011-09-15 | GSE27719 | GEO

Dual roles of RNF2 in melanoma progression

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-07-03 | E-GEOD-51930 | biostudies-arrayexpress

Contextual epigenetic regulation of lung adenocarcinoma by GATA6

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-03-05 | GSE124604 | GEO

Lung adenocarcinoma invasion and progression

Project description:This SuperSeries is composed of the following subset Series: GSE27675: Expression data from lung tumor and stromal cells of KrasTgfbr2 -/- mouse model GSE27716: Expression data from Columbia Lung Adenocarcinoma Human Tumor Cells GSE27717: Expression data from lung tumors of KrasTgfbr2 -/- mouse model Refer to individual Series

2011-09-14 | E-GEOD-27719 | biostudies-arrayexpress

Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma.

Project description: Not available

| S-EPMC4426948 | biostudies-literature

Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.

Project description: Not available

| S-EPMC7641015 | biostudies-literature

Hsa-miR-623 suppresses tumor progression in human lung adenocarcinoma.

Project description: Not available

| S-EPMC5059863 | biostudies-literature

The single cell transcriptional landscape of lung adenocarcinoma metastasis

Project description:This SuperSeries is composed of the SubSeries listed below.