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Modulating the Response to Benzo[a]pyrene when CYP1A1 and CYP1B1 are Knocked Down

ABSTRACT: Benzo[a]pyrene is a Group 1 carcinogen. It undergoes metabolism in the liver through CYP1A1 and CYP1B1 enzymes. This study was conducted to investigate the response to benzo[a]pyrene in the liver when these enzymes are knocked down.

ORGANISM(S): Homo sapiens

PROVIDER: GSE252339 | GEO | 2024/01/03

REPOSITORIES: GEO

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Cyp1b1-mediated suppression of lymphoid progenitors in bone marrow coordinately impacts spleen and thymus

Project description:C57BL/6j mice were treated with polycyclic aromatic hydrocarbons (benzo(a)pyrene, 7,12-dimethylbenz(a)anthracene, and 2,3,7,8 tetrachlorodibenzo-p-dioxin) Cyp1a1 and Cyp1b1 deletion separately and in combination were evaluated relative to the intact WT mice

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