Genetic background and aging-driven neuroimmune and disc changes underscore herniation susceptibility and pain-associated behaviors in SM/J mice

ABSTRACT: SM/J mice experience spontaneous age-associated intervertebral disc herniations, with molecular analyses indicating a dysregulated immune system may contribute to this disc pathology. To investigate this, we analyzed the circulating immune cells of these mice during aging, in relation to BL/6 mice, which do not experience disc herniation.

ORGANISM(S): Mus musculus

PROVIDER: GSE252474 | GEO | 2025/04/30

REPOSITORIES: GEO