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C. difficile's proline reductase harnesses host and commensal factors to drive efficient metabolism and progression to disease. Mono-association.

ABSTRACT: Gnotobiotic mice were mono-colonized with either the wild-type Clostridioides difficile ATCC 43255 strain or the proline reductase mutant (ΔprdB) of the ATCC 43255 strain. Cecal contents were collected and underwent RNASeq at the timepoints indicated below for pathway enrichment and transcritpmic analyses. Metatranscriptomic sequence processing was carried out as in Girinathan, et al, 2021 (PMID: 34637781)

ORGANISM(S): Mus musculus

PROVIDER: GSE252555 | GEO | 2026/06/09

REPOSITORIES: GEO

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C. difficile's proline reductase harnesses host and commensal factors to drive efficient metabolism and progression to disease. Commensal plus C. difficile.

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