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High-content phenotypic analysis defines generalizable genetic and molecular regulators of lifespan in a C. elegans recombinant inbred population

ABSTRACT: Background and Aims: Lifespan is influenced by complex interactions between genetic and environmental factors. Limitations in studying those factors in model organisms of a single genetic background hinder translational value. Here, we mapped genetic determinants of lifespans in 85 C. elegans recombinant intercross advanced inbred lines (RIAILs). We assessed molecular profiles – transcriptome, proteome, and lipidome – and life-history traits (lifespan), development, growth dynamics, and reproduction.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE252593 | GEO | 2024/02/07

REPOSITORIES: GEO

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