Sequencing of the influenza PR8 virus hemagglutinin Sb site mutant library

ABSTRACT: Current flu vaccine induces strong response to plastic and higly variable hemagglutinin (HA) head. However, response to conserved epitopes in HA elicited by current vaccine or infection is very limited. We hypothesized that change the relative "molarity" of immunodominant epitopes and conserved domain might increase response to conserved domains. Therfore, we made a library with the most ommunodominant domian Sb site randomized and tested its efficacy in vivo. Here we show the diversity of the library.

ORGANISM(S): Influenza A virus (A/Puerto Rico/8/1934(H1N1))

PROVIDER: GSE252606 | GEO | 2024/04/29

REPOSITORIES: GEO