Bulk-RNA sequencing of E8.25 posterior tissue +2 somites from controls and Sp5/8 double knockout or Wnt3a knockout embryos

ABSTRACT: Sp5/8 are Zn finger downstream transcription factors of Wnt/b-catenin signaling pathway. Deletion of Sp5/8 in mice result in severer posterior axis truncation by E9.5 closely resembling Wnt pathway mutants. The goal of this project is to identify differentially expressed genes between controls and Sp5/8 double knockout mutants that could potentially reveal mechanisms of the role of Sp5/8 factors in self-renewal and differentiation of caudal progenitors.

ORGANISM(S): Mus musculus

PROVIDER: GSE252659 | GEO | 2025/11/12

REPOSITORIES: GEO