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Kaempferol Improves Exercise Performance and Its Potential Mechanism

ABSTRACT: Kaempferol is a natural flavonoid with reported bioactivities, however its effects on exercise performance and muscle metabolism are unclear. This study investigated kaempferol for improving exercise performance and potential underlying mechanism in vivo and in vitro. In vitro, kaempferol promoted glucose uptake, protein synthesis and mitochondrial function along with decreasing oxidative stress in C2C12 myotubes. Moreover, the PI3K-AKT and MAPK signaling pathways were proved be activated with kaempferol by transcriptomic analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE252790 | GEO | 2024/02/02

REPOSITORIES: GEO

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