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Human peripheral nervous system SAGE

ABSTRACT: expression profiles generated from sciatic nerve as well as from Schwann cells cultured thereof Keywords: other

ORGANISM(S): Homo sapiens

PROVIDER: GSE2529 | GEO | 2005/04/16

SECONDARY ACCESSION(S): PRJNA92075

REPOSITORIES: GEO

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human peripheral nervous system SAGE

Project description:expression profiles generated from sciatic nerve as well as from Schwann cells cultured thereof Keywords: other

2005-04-16 | E-GEOD-2529 | biostudies-arrayexpress

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Project description:ChIP-seq of Sox10 in spinal cord and sciatic nerve was performed to determine shared and unique binding sites for Sox10 in oligodendrocytes and Schwann cells, respectively. Sox10 is required for both Schwann cell and oligodendrocyte development. In addition, differentiation of myelinating glia is dependent upon axonal signaling, so these studies were performed in vivo.

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Sox10 Binding Analysis in the Central and Peripheral Nervous System

Project description:ChIP-seq of Sox10 in spinal cord and sciatic nerve 2 independent Sox10 ChIP samples each for spinal cord (CNS) and sciatic nerve (PNS), with respective inputs

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Histone H3K4 trimethylation in rat peripheral nerve

Project description:ChIP-seq of H3K4me3 in rat peripheral nerve was used to identify transcription start sites associated with Schwann cell-expressed genes. The analysis was performed in injured and control nerve to identify injury-responsive changes in Schwann cells. H3K4me3 ChIP samples were prepared from rat sciatic nerve at 1 day post-transection using both the distal stump of the injured nerve and the contralateral (sham) nerve.

2016-08-01 | E-GEOD-84272 | biostudies-arrayexpress

Enhancer Analysis in Peripheral Nerve Injury

Project description:ChIP-seq of H3K27acetylation in sham and injured nerve. Schwann cells play an important role in the response of peripheral nerve to injury. This study was designed to identify enhancers that are altered in sciatic nerve at 3 days post-injury to help identify pathways that mediate the gene expression reprogramming that occurs in Schwann cells after nerve injury. We employed ChIP-seq analysis of H3K27 acetylation as a mark of actively engaged enhancers, and compared enhancers in the distal stump of transected sciatic nerve compared to contralateral (sham) condition.

2014-12-15 | GSE63103 | GEO

Role of Rnf40-dependent histone monoubiquitination in peripheral nervous system myelination [RNA-Seq]

Project description:To address the role of monoubiquitination of histone H2B at lysine 120 (H2Bub1), we inactivated the responsible E3 ligase by deleting Rnf40 in developing Schwann cells. Rnf40 becomes important for proper Schwann cell development shortly before and during differentiation. Its absence in Schwann cells leads to a peripheral neuropathy. RNA-Seq studies were performed on sciatic nerves from control mice and mice with a Schwann cell-specific deletion of Rnf40 to analyze changes in gene expression. These revealed substantial changes in the expression of genes associated with myelination, lipid metabolism and cell adhesion.

2020-07-13 | GSE146629 | GEO

Role of Rnf40-dependent histone monoubiquitination in peripheral nervous system myelination [ChIP-Seq]

Project description:To address the role of monoubiquitination of histone H2B at lysine 120 (H2Bub1), we inactivated the responsible E3 ligase by deleting Rnf40 in developing Schwann cells. Rnf40 becomes important for proper Schwann cell development shortly before and during differentiation. Its absence in Schwann cells leads to a peripheral neuropathy. ChIP-Seq studies with H2Bub1-specific antibodies were performed on sciatic nerves from control mice and mice with a Schwann cell-specific deletion of Rnf40 to detect alterations in genomic H2Bub1 occupancy. These correlated with changes in the expression of genes associated with myelination and lipid metabolism.

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FVB nerve x SC comparison

Project description:wild-type mouse (FVB strain) expression profiles of adult sciatic nerve and of cultured Schwann cell Keywords: other

2006-04-15 | GSE2530 | GEO

FVB nerve x SC comparison

Project description:wild-type mouse (FVB strain) expression profiles of adult sciatic nerve and of cultured Schwann cell Keywords: other

2006-04-15 | E-GEOD-2530 | biostudies-arrayexpress

Transcriptomic analysis of the peripheral nervous system of Schwann cell-conditional FASN knockout mice

Project description:Myelination calls for a tremendous surge in cell metabolism towards lipids and membrane production. However, functional relevance of de novo fatty acid synthesis in myelinating cells remains unclear. We generated mutant mice in which the enzyme fatty acid synthase (FASN) was depleted conditionally in Schwann cells, the myelinating glial cells of the peripheral nervous system. To address how lack of FASN was affecting the development of the peripheral nervous system, we screened with an Affymetrix Transcriptomic approach the transcriptome of sciatic nerves and roots of P60 FASN mutant mice, comparing to control mice.

2018-02-02 | GSE71373 | GEO

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