Genomics

Dataset Information

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Altered antisense-to-sense transcript ratios in breast cancer


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina Genome Analyzer (Homo sapiens)

SUBMITTER: Kornelia Polyak  

PROVIDER: GSE25292 | GEO | 2010-12-10

SECONDARY ACCESSION(S): PRJNA134891 GSE25291 GSE26000 GSE25932

REPOSITORIES: GEO

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Publications

Altered antisense-to-sense transcript ratios in breast cancer.

Maruyama Reo R   Shipitsin Michail M   Choudhury Sibgat S   Wu Zhenhua Z   Protopopov Alexei A   Yao Jun J   Lo Pang-Kuo PK   Bessarabova Marina M   Ishkin Alex A   Nikolsky Yuri Y   Liu X Shirley XS   Sukumar Saraswati S   Polyak Kornelia K  

Proceedings of the National Academy of Sciences of the United States of America 20101122 8


Transcriptome profiling studies suggest that a large fraction of the genome is transcribed and many transcripts function independent of their protein coding potential. The relevance of noncoding RNAs (ncRNAs) in normal physiological processes and in tumorigenesis is increasingly recognized. Here, we describe consistent and significant differences in the distribution of sense and antisense transcripts between normal and neoplastic breast tissues. Many of the differentially expressed antisense tra  ...[more]