Influence of GPR35 deficiency on the ileal and macrophage transcriptome

ABSTRACT: Mutations in GPR35 (G protein coupled receptor 35) are linked to ulcerative colitis and primary sclerosing cholangitis. How GPR35, which interacts with the Na/K-ATPase to determine ion transport, influences the transcriptome of macrophages and the ileum is unknown. Here compare transcript expression in bone marrow-derived macrophages and isolated ileum from mice deficient in GPR35 (knockout) with wild type mice by bulk RNA sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE252926 | GEO | 2025/02/07

REPOSITORIES: GEO