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Cardiac adventitial leptin receptor-expressing fibroblasts have a unique epigenetic landscape [mouse ATAC-Seq]

ABSTRACT: We performed ATAC (Assay for Transposase-Accessible Chromatin) sequencing of interstitial (LepR-Cre-) and adventitial (LepR-Cre+) cardiac fibroblasts in both the neonatal period (P7) and adulthood (P56). These ATAC-seq studies revealed that at P7 adventitial LepR-Cre+ cardiac fibroblasts and interstital LepR-Cre- cardiac fibroblasts exhibited abundant epigenomic differences.

ORGANISM(S): Mus musculus

PROVIDER: GSE253550 | GEO | 2026/01/18

REPOSITORIES: GEO

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RNA-sequencing comparing the transcriptome of adventitial LepR+ fibroblasts versus their interstitial LepR- counterparts. [mouse RNA-Seq]

Project description:In this study, we investigated the role of LepR-Cre+ cardiac fibroblasts (CFs). Our results reveal a specific gene expression profile of LepR-Cre+ CFs cells compared with LepR-Cre- CFs in both the postnatal period (P7) and adulthood (P56). Our findings support a model in which adventitial fibroblasts, being characterized by upregulation of genes involved in critical functions, including hedgehog signaling, blood pressure regulation, and interaction with the immune system, are major contributors in cardiac fibrosis.

2026-01-18 | GSE253547 | GEO

Expression data from cultured human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts

Project description:In order to find the difference between human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts for enhancing tumor formation ablity of human lung adenocarcinoma cell line A549, we found that human vascular adventitial fibroblasts enhance A549 tumor formation in vivo compared to human lung tissue-derived fibroblasts. To find the responsible genes for this phenomena, we used microarray analysis to find the expression difference between lung tissue-derived fibroblasts and vascular adventitial fibroblas Cultured human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts were analyzed in replicates.

2010-12-18 | E-GEOD-26146 | biostudies-arrayexpress

Leptin receptor marks and targets the hair follicle mesenchymal niche

Project description:We report the single-cell transcriptomes of whole, unsorted backskin skin cells isolated from P46 Lepr-Cre;mTmG;Smo and Lepr-Cre;mTmG;Smo+/- female mice and sorted Lepr-expressing, GFP-positive cells isolated from backskin of P50 Lepr-Cre;mTmG female mice

2022-05-16 | GSE160513 | GEO

RNA-sequencing transcriptome analysis suggested Gdf10 expression in adventitial CFs represents a mechanism for crosstalk with a distinct cardiac cell type [human RNA-seq]

Project description:Gdf10 encodes growth and differentiation factor 10, a member of the bone morphogenetic protein (BMP)/transforming growth factor-β (TGFβ) superfamily. Cardiac fibroblasts are known to express high levels of these receptors (used to transduce TGFβ signaling, a central pathway in fibroblast activation). In this study, we showed that adventitial fibroblasts express Gdf10 at higher levels than interstitial fibroblasts at both neonatal level and in adulthood, suggesting that it might represent a cell autonomous signaling mechanism. To test this, we conducted RNA-seq experiment in primary human cardiac fibroblasts subjected to recombinant GDF10. Whole transcriptome analysis revealed minimal alterations (only 4 moderately modulated genes), suggesting that rather than a cell autonomous mechanism, Gdf10 expression in adventitial CFs represents a mechanism for crosstalk with a distinct cardiac cell type.

2026-01-18 | GSE253545 | GEO

Expression data from cultured human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts

2010-12-18 | GSE26146 | GEO

P53-dependent Genes in Human Pulmonary Adventitial Fibroblasts

Project description:We report differentially expressed genes in human pulmonary arterial adventitial fibroblasts under genotoxic stress (Doxorubicin) or pharmacological p53-activation by Nutlin-3.

2021-03-03 | GSE154101 | GEO

Single-Cell RNA-Seq Reveals Adventitial Fibroblast Alterations during Mouse Atherosclerosis

Project description:Background: Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality in the western world despite the success of lipid lowering therapies, highlighting the need for novel lipid-independent therapeutic strategies. Genome-wide association studies (GWAS) have identified numerous genes associated with ASCVD that appear to predominantly function in the vessel wall, suggesting both that vascular cells mediate ASCVD, and that the genes and pathways essential for this vascular cell function may be novel therapeutic targets for the treatment of ASCVD. Furthermore, some of these implicated genes appear to function in the adventitial layer of the vasculature, suggesting these cells are able to potentiate ASCVD. Methods: To investigate the contribution of adventitial cells in atherosclerosis, we conducted single-cell RNA sequencing (scRNA-seq) of the aortic adventitia during atherogenesis in male Ldlr-/- mice via pools of three mice, two samples per condition. We cross-referenced the scRNA-seq data with human ASCVD GWAS to identify regulators of adventitial responses in ASCVD. These regulators were then validated in vitro in human adventitial fibroblasts. Results: We identified four adventitial fibroblast populations, all of which displayed shifts in population size and gene expression over the course of atherogenesis. SERPINH1, an ASCVD-linked GWAS gene, was differentially expressed in adventitial fibroblasts during atherogenesis. Knockdown of SERPINH1 in vitro reduced fibroblast migration and altered subcluster marker gene expression. Conclusions: These findings reveal dynamic changes in adventitial fibroblasts during atherosclerosis and suggest that reduced SERPINH1 expression disrupts adventitial fibroblast function, contributing to ASCVD progression.

2025-10-22 | GSE289281 | GEO

Targeted RNA sequencing of varicella zoster virus-infected human brain vascular adventitial fibroblasts

Project description:Transcriptome analysis of VZV infected primary human brain vascular adventitial fibroblasts (HBVAFs)

2021-11-17 | GSE175797 | GEO

P53-dependent Genes in Human Pulmonary Adventitial Fibroblasts

Project description:P53-dependent Genes in Human Pulmonary Adventitial Fibroblasts

| PRJNA645130 | ENA

Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

Project description:Goal of the study was to evalaute gene expression changes in donor PASMC upon co-culture with IPAH PAAF (diseased pulmonary artery adventitial fibroblasts) compared to baseline (co-culture with source-matched donor PAAF).

2025-04-07 | GSE262069 | GEO

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