Phase separation of YAP-MAML2 differentially regulates the transcriptome

ABSTRACT: SPARK-OFF tag does not perturb the core transcriptional function of YAP-MAML2.~2260 DEGs with ≥ 1.5-fold change in transcript level, including ~1270 up-regulated genes and ~990 down-regulated genes can be identified from YAP-MAML2 overexpression HEK293T cells.We identified 88 DEGs (p-value < 0.01, |Log2FC| ≥ 0.58, FDR < 0.1) that are regulated by YAP-MAML2 phase separation with ≥ 1.5-fold change in transcript levels, including 44 up-regulated genes and 44 down-regulated genes

ORGANISM(S): Homo sapiens

PROVIDER: GSE253678 | GEO | 2024/01/23

REPOSITORIES: GEO