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Scd-1 deficiency promotes the differentiation of CD8+ T effector

ABSTRACT: The impact of various fatty acid types on adaptive immunity remains uncertain, and their roles remain unelucidated. In this study, we showed that the enzyme stearoyl-CoA desaturase-1 (Scd-1) and its resulting compound, oleic acid (OA), have a substantial impact on the transformation of CD8+ naïve T cells into effector T cells. Inactivation of Scd-1 triggers the specialization of CD8+ T cells into the Teff subset, enhancing the effector function and mitochondrial metabolism of Teff cells, and OA can partially counteract this.

ORGANISM(S): Mus musculus

PROVIDER: GSE253770 | GEO | 2024/01/25

REPOSITORIES: GEO

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Regulation of SCD and fatty acid saturation by MITF controls melanoma phenotypic plasticity

Project description:The ability of cancer cells to switch phenotype in response to a dynamic intra-tumor microenvironment is a major barrier to effective therapy. In melanoma, down-regulation of the lineage addiction oncogene MITF (Microphthalmia-associated transcription factor) is a hallmark of the proliferative-to-invasive phenotype switch. Yet how MITF promotes proliferation and suppresses invasion is poorly understood. Here we show that expression of the key lipogenic enzyme stearoyl-CoA desaturase (SCD) is activated by MITF, but suppressed by the stress-responsive transcription factor ATF4. SCD expression is required for MITF-positive melanoma cell proliferation,. By contrast, MITF-low cells express reduced levels of SCD and are insensitive to its inhibition, indicating that cell phenotype dictates response to drugs targeting lipid metabolism. Since SCD suppresses inflammatory signalling and ATF4 expression, the results identify a positive feedback-loop that can maintain an invasive phenotype, uncover a key role for MITF and ATF4 in metabolic reprograming, and reveal fatty acid composition as a driver of melanoma phenotype-switching.

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scd

Project description:Danio rerio scd, stearoyl-CoA desaturase (delta-9-desaturase) [Source:ZFIN;Acc:ZDB-GENE-031106-3], is expressed in 1 baseline experiment(s);

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scd

Project description:Danio rerio scd, stearoyl-CoA desaturase (delta-9-desaturase) [Source:ZFIN;Acc:ZDB-GENE-031106-3], is differentially expressed in 1 experiment(s);

| ENSDARG00000033662 | ExpressionAtlas

Scd

Project description:Rattus norvegicus Scd, stearoyl-CoA desaturase [Source:RGD Symbol;Acc:621176], is differentially expressed in 38 experiment(s);

| ENSRNOG00000013552 | ExpressionAtlas

Scd

Project description:Rattus norvegicus Scd, stearoyl-CoA desaturase [Source:RGD Symbol;Acc:621176], is expressed in 6 baseline experiment(s);

| ENSRNOG00000013552 | ExpressionAtlas

SCD

Project description:Monodelphis domestica SCD, stearoyl-CoA desaturase [Source:NCBI gene;Acc:100014196], is expressed in 2 baseline experiment(s);

| ENSMODG00000010632 | ExpressionAtlas

SCD

Project description:Anas platyrhynchos SCD, stearoyl-CoA desaturase [Source:HGNC Symbol;Acc:HGNC:10571], is differentially expressed in 1 experiment(s);

| ENSAPLG00000015665 | ExpressionAtlas

SCD

Project description:Macaca mulatta SCD, stearoyl-CoA desaturase [Source:HGNC Symbol;Acc:HGNC:10571], is expressed in 2 baseline experiment(s);

| ENSMMUG00000058462 | ExpressionAtlas

SCD

Project description:Homo sapiens SCD, stearoyl-CoA desaturase [Source:HGNC Symbol;Acc:HGNC:10571], is differentially expressed in 256 experiment(s);

| ENSG00000099194 | ExpressionAtlas

SCD

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