RNA-Seq reveals heterogeneity in the submandibular glands and submandibular gland draining lymph nodes of SS mice

ABSTRACT: In this study, we analyzed the submandibular glands of P40-/-CD25+/- (control mice) and P40-/-CD25-/- (SS mice) after PD-1-targeted CAR-T cells or control T cells treatment using RNA-Seq. We found that the transcription of inflammatory genes was down-regulated and the transcription of tissue repair genes was up-regulated in the submandibular glands of SS mice after PD-1-targeted CAR-T cells treatment. In addition, PD-1+Tigit+CD8+ T cells in the submandibular gland draining lymph nodes of SS mice showed transcription characteristics of tissue resident memory precursors.

ORGANISM(S): Mus musculus

PROVIDER: GSE253818 | GEO | 2024/12/15

REPOSITORIES: GEO